2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P4469
    PRL 3195 341519-04-8 98%
    PRL 3195 is a somatostatin receptor antagonist with Kis of 6, 17, 66, 1000 and 1000 nM for human somatostatin receptors (sst5, sst2, sst3, sst1 and sst4, respectively).
    PRL 3195
  • HY-P4682
    Neuromedin U-25 (porcine) 98395-76-7 98.17%
    Neuromedin U-25 (porcine) is a uterus stimulating and hypertensive peptides.
    Neuromedin U-25 (porcine)
  • HY-P4683
    (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin 129520-65-6 98%
    (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin is a potent vasopressin V1 receptor (VP V1R) antagonist. (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin significantly decreases the mean arterial pressure (MAP) in rats.
    (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin
  • HY-P5059
    Dendroaspis Natriuretic Peptide 255721-52-9
    Dendroaspis Natriuretic Peptide is a vasodilator peptide that can be isolated from animal venom.
    Dendroaspis Natriuretic Peptide
  • HY-P5767
    Fibrinogen γ-chain (117-133) 160927-63-9 99.88%
    Fibrinogen γ-chain (117-133) is a selective intercellular adhesion molecule-1 (ICAM-1) inhibitor (IC50≈20-40 μg/mL). Fibrinogen γ-chain (117-133) blocks fibrinogen-mediated monocyte-endothelial adhesion. Fibrinogen γ-chain (117-133) is promising for research of thrombo-inflammatory diseases (e.g., atherosclerosis, organ transplant rejection).
    Fibrinogen γ-chain (117-133)
  • HY-P6023
    D-Leu-Pro-Arg-Rh110-D-Pro 98%
    D-Leu-Pro-Arg-Rh110-D-Pro is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro can be used to detect FXIa activity.
    D-Leu-Pro-Arg-Rh110-D-Pro
  • HY-100119
    Enecadin 259525-01-4 98.51%
    Enecadin is a neuroprotective agent extracted from patent US 8623823 B2.
    Enecadin
  • HY-100217
    DL-3-Indolylglycine 6747-15-5 98.16%
    DL-3-Indolylglycine is a compound intermediate and Amino acid derivative. DL-3-Indolylglycine can be used for the synthesis of serine protease inhibitors. DL-3-Indolylglycine is applicable to the research of thrombotic diseases.
    DL-3-Indolylglycine
  • HY-100240
    Lodelaben 111149-90-7
    Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively.
    Lodelaben
  • HY-100298
    Caldaret 133804-44-1 98.35%
    Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition.
    Caldaret
  • HY-100300
    AGN 192836 171102-29-7 99.49%
    AGN 192836 is a potent and selective α2 adrenergic agonist with EC50s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.
    AGN 192836
  • HY-100572
    Nicainoprol 76252-06-7 99.86%
    Nicainoprol is a fast-sodium-channel blocking agent, which is a potent antiarrhythmic agent.
    Nicainoprol
  • HY-100615
    Revizinone 133718-29-3 99.75%
    Revizinone is a novel selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.
    Revizinone
  • HY-100718
    SCH00013 217963-18-3 98%
    SCH00013 is a cardiotonic that primarily increases the sensitivity of muscle fibers to Ca++.
    SCH00013
  • HY-100796
    Guanoclor 5001-32-1 99.34%
    Guanoclor is an antihypertensive compound. Guanoclor is an adrenergic neurone-blocking agent, which also interferes with noradrenaline synthesis by inhibition of the enzyme dopamine beta-hydroxylase.
    Guanoclor
  • HY-100826
    TN1 289479-94-3
    TN1 is a potent fetal hemoglobin (HbF) inducer.
    TN1
  • HY-101308
    MRS2179 tetrasodium 1454889-37-2 98%
    MRS2179 tetrasodium is a competitive P2Y1 receptor antagonist, with a Kb of 102 nM and a pA2 of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium is selective for P2Y1 over P2X1 (IC50=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors. MRS2179 tetrasodium inhibits platelet aggregation.
    MRS2179 tetrasodium
  • HY-101327
    Xamoterol 81801-12-9 98%
    Xamoterol (Corwin; ICI 118587) is an orally active and selective β1-adrenoceptor partial agonist. Xamoterol acts as agonist at low sympathetic tone, antagonist at high sympathetic tone, with context-dependent cardiovascular effects including modulated heart rate, blood pressure, and cardiac output. Xamoterol can be used for the research of heart failure, postural hypotension, and ischemic heart disease.
    Xamoterol
  • HY-101554
    Guancydine 1113-10-6 98.0%
    Guancydine (Guancidine) is an orally active antihypertensive agent and vasodilator. Guancydine antagonizes the pressor effects of Angiotensin and Norepinephrine (HY-13715). Guancydine induces vasodilation in renal, mesenteric and cranial vascular beds, reduces peripheral resistance, increases cardiac output and lowers arterial blood pressure. Guancydine increases renal and forearm blood flow, reduces renal and forearm vascular resistance, alters cardiac systolic time, and reverses myocardial hypertrophy in hypertensive rats. Guancydine is applicable for research related to hypertension.
    Guancydine
  • HY-101605
    Prodipine hydrochloride 31314-39-3 99.84%
    Prodipine, a diphenyl-phosphonate derivative. The IC50s of Prodipine for purified and plasma Dipeptidyl peptidase IV (DPP IV) from the rabbit are 4.5 μM and 30 μM, respectively.
    Prodipine hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity